Calum A. MacRae, MD, PhD, is Professor of Medicine at Harvard Medical School, the Director of One Brave Idea (a biomedical innovation program founded by Verily, the American Heart Association and AstraZeneca), Vice Chair for Scientific Innovation in the Department of Medicine at Brigham and Women’s Hospital in Boston, a Principal Faculty Member at the Harvard Stem Cell Institute, and an Associate Member at the Broad Institute of Harvard and MIT. He is the principal investigator of the Apple Heart & Movement study and a large research collaboration with Samsung Inc. and is working on the integration of digital health and genomics. He also directs an NIH-funded basic science group which exploits the interface between biology and technology to uncover novel human disease mechanisms and therapies. In his clinical work, he is a Cardiologist and Geneticist, co-directs the Genomic Medicine Program at Brigham and Women’s Hospital and is a clinical lead in the Harvard Undiagnosed Diseases Center. His team has created rigorous approaches to automating components of medicine to enable coordinated approaches to care delivery, translation and basic discovery, and the creation of proprietary foundation models for biomedicine. He is a co-founder of Atman Health, a disease management automation company, and Tanaist a platform for precision medicine.