Rudolph Tanzi, PhD

Dr. Rudolph Tanzi is the Director of the Genetics and Aging Research Unit, Co-Director of the McCance Center for Brain Health, Co-Director of the MassGeneral Institute for Neurodegenerative Disease, and Vice-Chair of Neurology (Research), at Massachusetts General Hospital. He is also the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School. Dr. Tanzi co-discovered the three early-onset familial Alzheimer’s disease (AD) genes and several other AD genes. Dr. Tanzi’s lab used human stem cells to create 3D neural-glial culture models of AD, which were the first to recapitulate all three pathological hallmarks of AD. He has used these models to screen for known drugs that can be repurposed to treat AD. Dr. Tanzi has also helped develop novel therapies for AD including gamma secretase modulators (Phase 1 trial in 2023) and Relyvrio™, which has been approved for treating ALS. Dr. Tanzi has published over 600 papers, received numerous awards, including the Metropolitan Life Award, Potamkin Prize, and Smithsonian American Ingenuity Award, and on the TIME100 Most Influential People in the World. Dr. Tanzi is also a New York Times bestselling author, who co-authored Decoding Darkness, Super Brain, Super Genes, and The Healing Self, for which he has hosted several television shows on PBS.

Director, Genetics and Aging Research Unit,

Co-Director, McCance Center for Brain Health, MGH;

Joseph P. and Rose F. Kennedy Professor of Neurology, HMS


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